用于實(shí)驗(yàn)室、PET、CT、SPECT、光學(xué)、核磁環(huán)境中處于麻醉狀態(tài)下的大小鼠以及其他稍大動(dòng)物的生理監(jiān)測(cè)和門控成像。

小動(dòng)物監(jiān)護(hù)&門控系統(tǒng)系統(tǒng)用于麻醉大小鼠及較大動(dòng)物生理狀態(tài)監(jiān)護(hù)，可以搭配核磁兼容裝置，核磁環(huán)境下監(jiān)護(hù)大小鼠心電、呼吸和體溫，模塊化設(shè)計(jì)使用更加簡(jiǎn)單方便。該系統(tǒng)包括一個(gè)ERT模塊和一個(gè)ERT控制器，PC可顯示多個(gè)波形、測(cè)量值和趨勢(shì)。門控通過(guò)監(jiān)測(cè)動(dòng)物的心電呼吸信號(hào),將圖像采集與心臟和呼吸的特定時(shí)相相匹配，舍棄一些主動(dòng)運(yùn)動(dòng)期間的信號(hào)采集，通過(guò)對(duì)運(yùn)動(dòng)的監(jiān)測(cè)來(lái)達(dá)到抑制運(yùn)動(dòng)偽影的效果，增強(qiáng)圖像質(zhì)量。

優(yōu)勢(shì)特點(diǎn)：

1. 可在CT、PET、SPECT、光學(xué)成像、正常實(shí)驗(yàn)環(huán)境工作
2. PC實(shí)時(shí)顯示監(jiān)測(cè)生理參數(shù)波形及數(shù)值、門控點(diǎn)設(shè)置等信息
3. 模塊化設(shè)計(jì)，用戶根據(jù)需求選配，節(jié)約實(shí)驗(yàn)成本
4. 可監(jiān)測(cè)呼吸心電體溫等參數(shù)
5. R波門控延遲可由用戶設(shè)置，呼吸門控寬度可由用戶設(shè)置
6. 可選配脈搏血氧、EtCO2、有創(chuàng)血壓、光纖測(cè)溫及通氣輔助等功能
7. 可搭配核磁兼容模塊，兼容MR環(huán)境，可在高磁場(chǎng)環(huán)境下工作

應(yīng)用領(lǐng)域：

小動(dòng)物核磁兼容監(jiān)護(hù)&門控系統(tǒng)廣泛應(yīng)用于各種MR、MRI、CT、PET CT成像中，將圖像采集與心臟和呼吸的特定時(shí)相相匹配，舍棄一些主動(dòng)運(yùn)動(dòng)期間的信號(hào)采集，通過(guò)對(duì)運(yùn)動(dòng)的監(jiān)測(cè)來(lái)達(dá)到抑制運(yùn)動(dòng)偽影的效果，增強(qiáng)圖像質(zhì)量。

圖為小鼠主動(dòng)脈根部：9.4T垂直場(chǎng)；心電圖和呼吸門控；90秒圖像，無(wú)對(duì)比度

圖為西門子7.0Tterra科研臨床兩用磁共振， 安裝SAll動(dòng)物門控掃描減少偽影和心電監(jiān)護(hù)

圖為門控有創(chuàng)血壓模塊監(jiān)測(cè)股動(dòng)脈

圖為1030型在核磁環(huán)境下應(yīng)用于靈長(zhǎng)類動(dòng)物顱腦部的監(jiān)護(hù)門控

部分用戶名單：

型號(hào)規(guī)格：

參考文獻(xiàn)：

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2.Alvarado, Roman et al. “Real-time imaging of decompression gas bubble growth in the spinal cord of live rats.” Magnetic resonance in medicine, 10.1002/mrm.30128. 23 Apr. 2024, doi:10.1002/mrm.30128
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5.Schweins, Moritz et al. “Multi-modal assessment of a cardiac stem cell therapy reveals distinct modulation of regional scar properties.” Journal of translational medicine vol. 22,1 187. 21 Feb. 2024, doi:10.1186/s12967-024-04986-2
6.Chan, Dennis C et al. “Cytokine expression patterns predict suppression of vulnerable neural circuits in a mouse model of Alzheimer's disease.” bioRxiv : the preprint server for biology 2024.03.17.585383. 17 Mar. 2024, doi:10.1101/2024.03.17.585383. Preprint.
7.Yen, Tin-Yo C et al. “Biocompatible and bioactivable terpolymer-lipid-MnO2 Nanoparticle-based MRI contrast agent for improving tumor detection and delineation.” Materials today. Bio vol. 25 100954. 17 Jan. 2024, doi:10.1016/j.mtbio.2024.100954
8.Suarez, Aileen C et al. “Pregnancy-induced remodeling of the murine reproductive tract: a longitudinal in vivo magnetic resonance imaging study.” Scientific reports vol. 14,1 586. 5 Jan. 2024, doi:10.1038/s41598-023-50437-1
9.Robinson, Gain et al. “Multimodal Imaging Reveals that Sustained Inhibition of HIF-Prolyl Hydroxylases Induces Opposing Effects on Right and Left Ventricular Function in Healthy Rats.” Molecular imaging and biology vol. 26,1 (2024): 179-187. doi:10.1007/s11307-023-01876-9
10.Zhao, Qiulong et al. “Phytomedicine Fructus Aurantii-derived two absorbed compounds unlock antidepressant and prokinetic multi-functions via modulating 5-HT3/GHSR.” Journal of ethnopharmacology vol. 323 (2024): 117703. doi:10.1016/j.jep.2024.117703
11.Hune, Theresa et al. “Metabolic Tumor Imaging with Rapidly Signal-Enhanced 1-13 C-Pyruvate-d3.” Chemphyschem : a European journal of chemical physics and physical chemistry vol. 24,2 (2023): e202200615. doi:10.1002/cphc.202200615
12.Wunker, Claire et al. “Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model.” Journal of visualized experiments : JoVE ,191 10.3791/64544. 13 Jan. 2023, doi:10.3791/64544
13.Burns, Jennie M et al. “Dilation of the superior sagittal sinus detected in rat model of mild traumatic brain injury using 1?T magnetic resonance imaging.” Frontiers in neurology vol. 14 1045695. 26 Apr. 2023, doi:10.3389/fneur.2023.1045695
14.Jendritza, Patrick et al. “Multi-area recordings and optogenetics in the awake, behaving marmoset.” Nature communications vol. 14,1 577. 2 Feb. 2023, doi:10.1038/s41467-023-36217-5
Cabral, Joana et al. “Intrinsic macroscale oscillatory modes driving long range functional connectivity in female rat brains detected by ultrafast fMRI.” Nature communications vol. 14,1 375. 6 Feb. 2023, doi:10.1038/s41467-023-36025-x

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